Drug interactions
Buprenorphine + Dextromoramide
Severity: Major
Buprenorphine and Dextromoramide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent full mu agonist, and buprenorphine can reduce its analgesic effect or precipitate withdrawal in opioid-dependent patients. Both also cause additive sedation and respiratory depression.
What this interaction means in plain words
Buprenorphine and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Partial versus full mu-opioid agonist competition, with additive CNS depression.
What to do
Avoid concurrent use and choose a single opioid strategy. If both are given, monitor for withdrawal, poor analgesia and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Frequently asked questions
Can I take Buprenorphine with Dextromoramide?
MediHelp rates the interaction as major. Buprenorphine and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dextromoramide is a potent full mu agonist, and buprenorphine can reduce its analgesic effect or precipitate withdrawal in opioid-dependent patients. Both also cause additive sedation and respiratory depression.
How serious is the interaction between Buprenorphine and Dextromoramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a single opioid strategy. If both are given, monitor for withdrawal, poor analgesia and respiratory depression.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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