Drug interactions
Buprenorphine + Fexinidazole
Severity: Major
Buprenorphine and Fexinidazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole prolongs the QT interval and may inhibit CYP3A4, which could raise buprenorphine levels. The combination may increase both arrhythmia risk and opioid adverse effects such as sedation.
What this interaction means in plain words
Buprenorphine and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation plus CYP3A4 inhibition that may increase buprenorphine exposure.
What to do
Avoid if an alternative analgesic or opioid substitution therapy is feasible. If unavoidable, monitor ECG, electrolytes and signs of opioid excess.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Frequently asked questions
Can I take Buprenorphine with Fexinidazole?
MediHelp rates the interaction as major. Buprenorphine and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole prolongs the QT interval and may inhibit CYP3A4, which could raise buprenorphine levels. The combination may increase both arrhythmia risk and opioid adverse effects such as sedation.
How serious is the interaction between Buprenorphine and Fexinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative analgesic or opioid substitution therapy is feasible. If unavoidable, monitor ECG, electrolytes and signs of opioid excess.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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