Drug interactions
Buprenorphine + Loxapine inhaled
Severity: Moderate
Buprenorphine and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine is sedating and can cause bronchospasm, and an opioid adds to CNS depression. Together they may cause excess drowsiness and reduced respiratory drive.
What this interaction means in plain words
Buprenorphine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from the antipsychotic and the opioid.
What to do
Monitor sedation level and respiratory status after loxapine dosing. Give loxapine only where bronchospasm can be managed, and reduce doses if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Frequently asked questions
Can I take Buprenorphine with Loxapine inhaled?
MediHelp rates the interaction as moderate. Buprenorphine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine is sedating and can cause bronchospasm, and an opioid adds to CNS depression. Together they may cause excess drowsiness and reduced respiratory drive.
How serious is the interaction between Buprenorphine and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status after loxapine dosing. Give loxapine only where bronchospasm can be managed, and reduce doses if oversedation occurs.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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