Drug interactions
Buprenorphine + Methylenedioxymethamphetamine
Severity: Moderate
Buprenorphine and Methylenedioxymethamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a serotonin-releasing stimulant that may mask the sedation caused by buprenorphine, leading to unrecognized opioid effect. Both drugs can also affect serotonergic and cardiovascular function, and the overall effect is unpredictable.
What this interaction means in plain words
Buprenorphine and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS stimulant and depressant effects with possible serotonergic overlap; the net interaction is not well characterized.
What to do
Advise against concurrent use of MDMA with buprenorphine. Monitor for respiratory depression once the stimulant effect wears off, and for signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Frequently asked questions
Can I take Buprenorphine with Methylenedioxymethamphetamine?
MediHelp rates the interaction as moderate. Buprenorphine and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is a serotonin-releasing stimulant that may mask the sedation caused by buprenorphine, leading to unrecognized opioid effect. Both drugs can also affect serotonergic and cardiovascular function, and the overall effect is unpredictable.
How serious is the interaction between Buprenorphine and Methylenedioxymethamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against concurrent use of MDMA with buprenorphine. Monitor for respiratory depression once the stimulant effect wears off, and for signs of serotonin toxicity.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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