Drug interactions
Buprenorphine + Metoclopramide intranasal
Severity: Moderate
Buprenorphine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids reduce gastrointestinal motility and oppose the prokinetic effect of metoclopramide, and both can cause CNS depression. Metoclopramide may also add to sedation and extrapyramidal effects.
What this interaction means in plain words
Buprenorphine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism of gastric motility and additive CNS depression.
What to do
Monitor for reduced antiemetic or prokinetic benefit and for sedation. Consider an alternative antiemetic if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Frequently asked questions
Can I take Buprenorphine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Buprenorphine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids reduce gastrointestinal motility and oppose the prokinetic effect of metoclopramide, and both can cause CNS depression. Metoclopramide may also add to sedation and extrapyramidal effects.
How serious is the interaction between Buprenorphine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antiemetic or prokinetic benefit and for sedation. Consider an alternative antiemetic if the response is inadequate.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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