Drug interactions
Buprenorphine + Octreotide
Severity: Moderate
Buprenorphine and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and buprenorphine may add a small QT effect. The combined risk is generally modest but relevant in patients with cardiac disease.
What this interaction means in plain words
Buprenorphine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Octreotide belongs to Endocrine.
Why it happens
Additive effects on cardiac conduction and repolarization, with octreotide-related bradycardia.
What to do
Monitor heart rate and ECG in patients with cardiac risk factors and keep electrolytes normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Buprenorphine with Octreotide?
MediHelp rates the interaction as moderate. Buprenorphine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and buprenorphine may add a small QT effect. The combined risk is generally modest but relevant in patients with cardiac disease.
How serious is the interaction between Buprenorphine and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with cardiac risk factors and keep electrolytes normal.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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