Drug interactions
Buprenorphine + Triprolidine
Severity: Moderate
Buprenorphine and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedating antihistamine with buprenorphine increases sedation and, at higher doses, can contribute to respiratory depression.
What this interaction means in plain words
Buprenorphine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS and respiratory depression.
What to do
Use a non-sedating antihistamine if possible. If combined, monitor sedation and respiratory status, and counsel against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Frequently asked questions
Can I take Buprenorphine with Triprolidine?
MediHelp rates the interaction as moderate. Buprenorphine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sedating antihistamine with buprenorphine increases sedation and, at higher doses, can contribute to respiratory depression.
How serious is the interaction between Buprenorphine and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-sedating antihistamine if possible. If combined, monitor sedation and respiratory status, and counsel against driving and alcohol.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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