Drug interactions
Buprenorphine buccal + Pimozide
Severity: Major
Buprenorphine buccal and Pimozide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can prolong the QT interval, especially at higher doses, and pimozide is a strong QT-prolonging drug. Together they may increase the risk of torsades de pointes, with additive sedation also possible.
What this interaction means in plain words
Buprenorphine buccal and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation; additive CNS depression.
What to do
Avoid if possible; if used, take baseline and follow-up ECGs and correct potassium and magnesium. Use the lowest effective buprenorphine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Pimozide?
MediHelp rates the interaction as major. Buprenorphine buccal and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Buprenorphine can prolong the QT interval, especially at higher doses, and pimozide is a strong QT-prolonging drug. Together they may increase the risk of torsades de pointes, with additive sedation also possible.
How serious is the interaction between Buprenorphine buccal and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used, take baseline and follow-up ECGs and correct potassium and magnesium. Use the lowest effective buprenorphine dose.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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