Drug interactions
Buprenorphine long-acting + Dextroamphetamine
Severity: Moderate
Buprenorphine long-acting and Dextroamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamine increases serotonin release and buprenorphine has been associated with serotonin syndrome. Together they may increase the risk of serotonin toxicity, which can be severe. Long-acting injection cannot be quickly withdrawn if toxicity develops.
What this interaction means in plain words
Buprenorphine long-acting and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity.
What to do
Monitor for agitation, tremor, hyperreflexia, sweating and fever after starting or changing doses. Stop the stimulant and provide supportive care if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Dextroamphetamine?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamine increases serotonin release and buprenorphine has been associated with serotonin syndrome. Together they may increase the risk of serotonin toxicity, which can be severe. Long-acting injection cannot be quickly withdrawn if toxicity develops.
How serious is the interaction between Buprenorphine long-acting and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia, sweating and fever after starting or changing doses. Stop the stimulant and provide supportive care if serotonin syndrome is suspected.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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