Drug interactions
Buprenorphine long-acting + Isoniazid
Severity: Moderate
Buprenorphine long-acting and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits CYP3A4, which may increase buprenorphine plasma levels from the long-acting injection. Because the depot cannot be quickly withdrawn, excess opioid effects may persist.
What this interaction means in plain words
Buprenorphine long-acting and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by isoniazid reduces buprenorphine clearance.
What to do
Monitor for sedation and respiratory depression, especially in the first weeks. Switch to an adjustable transmucosal formulation if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Buprenorphine long-acting with Isoniazid?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid inhibits CYP3A4, which may increase buprenorphine plasma levels from the long-acting injection. Because the depot cannot be quickly withdrawn, excess opioid effects may persist.
How serious is the interaction between Buprenorphine long-acting and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, especially in the first weeks. Switch to an adjustable transmucosal formulation if toxicity occurs.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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