Drug interactions
Buprenorphine long-acting + Olanzapine
Severity: Moderate
Buprenorphine long-acting and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents may prolong the QT interval, so co-use may add to arrhythmia risk, mainly in predisposed patients. Because the long-acting injection persists for weeks, the exposure cannot be quickly withdrawn. Additive sedation is also possible.
What this interaction means in plain words
Buprenorphine long-acting and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization, plus additive CNS depression.
What to do
Assess ECG and electrolytes in patients with other QT risk factors. Monitor for sedation, palpitations and syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Buprenorphine long-acting with Olanzapine?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents may prolong the QT interval, so co-use may add to arrhythmia risk, mainly in predisposed patients. Because the long-acting injection persists for weeks, the exposure cannot be quickly withdrawn. Additive sedation is also possible.
How serious is the interaction between Buprenorphine long-acting and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess ECG and electrolytes in patients with other QT risk factors. Monitor for sedation, palpitations and syncope.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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