Drug interactions
Buprenorphine long-acting + Pimozide
Severity: Major
Buprenorphine long-acting and Pimozide: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting injectable buprenorphine can contribute to QT prolongation, which adds to the strong effect of pimozide. Because the depot cannot be stopped quickly, the risk is prolonged.
What this interaction means in plain words
Buprenorphine long-acting and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation; additive CNS depression.
What to do
Avoid if possible and consider a non-QT-prolonging alternative to pimozide. Monitor ECG and electrolytes if both are required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Pimozide?
MediHelp rates the interaction as major. Buprenorphine long-acting and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Long-acting injectable buprenorphine can contribute to QT prolongation, which adds to the strong effect of pimozide. Because the depot cannot be stopped quickly, the risk is prolonged.
How serious is the interaction between Buprenorphine long-acting and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and consider a non-QT-prolonging alternative to pimozide. Monitor ECG and electrolytes if both are required.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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