Drug interactions
Buprenorphine subdermal implant + Chlordiazepoxide
Severity: Major
Buprenorphine subdermal implant and Chlordiazepoxide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent benzodiazepine and buprenorphine use increases the risk of profound sedation, respiratory depression, coma and death. The implant gives continuous exposure for months, so the risk persists.
What this interaction means in plain words
Buprenorphine subdermal implant and Chlordiazepoxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid receptor agonism and GABA-A potentiation.
What to do
Avoid unless alternatives are inadequate; if used, keep benzodiazepine dose and duration minimal. Monitor for sedation and respiratory depression and educate patient and carers on warning signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Buprenorphine subdermal implant with Chlordiazepoxide?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Chlordiazepoxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent benzodiazepine and buprenorphine use increases the risk of profound sedation, respiratory depression, coma and death. The implant gives continuous exposure for months, so the risk persists.
How serious is the interaction between Buprenorphine subdermal implant and Chlordiazepoxide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless alternatives are inadequate; if used, keep benzodiazepine dose and duration minimal. Monitor for sedation and respiratory depression and educate patient and carers on warning signs.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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