Drug interactions
Buprenorphine subdermal implant + Clonidine
Severity: Moderate
Buprenorphine subdermal implant and Clonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and lower blood pressure and heart rate. Combined use may add to drowsiness, respiratory depression and hypotension.
What this interaction means in plain words
Buprenorphine subdermal implant and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and hypotensive effects of alpha-2 agonism and opioid activity.
What to do
Monitor sedation, respiratory rate and blood pressure, especially when clonidine is started or increased. Reduce the clonidine dose if excessive sedation or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Buprenorphine subdermal implant with Clonidine?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and lower blood pressure and heart rate. Combined use may add to drowsiness, respiratory depression and hypotension.
How serious is the interaction between Buprenorphine subdermal implant and Clonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate and blood pressure, especially when clonidine is started or increased. Reduce the clonidine dose if excessive sedation or hypotension develops.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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