Drug interactions
Buprenorphine subdermal implant + Donepezil
Severity: Moderate
Buprenorphine subdermal implant and Donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can modestly lengthen the QT interval, and donepezil has a recognized torsades risk. Together they may increase the chance of an arrhythmia in patients with other risk factors.
What this interaction means in plain words
Buprenorphine subdermal implant and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Review other QT-prolonging drugs and correct electrolytes. Obtain an ECG in patients with cardiac disease, syncope or palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Buprenorphine subdermal implant with Donepezil?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can modestly lengthen the QT interval, and donepezil has a recognized torsades risk. Together they may increase the chance of an arrhythmia in patients with other risk factors.
How serious is the interaction between Buprenorphine subdermal implant and Donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review other QT-prolonging drugs and correct electrolytes. Obtain an ECG in patients with cardiac disease, syncope or palpitations.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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