Drug interactions
Buprenorphine subdermal implant + Isoniazid
Severity: Moderate
Buprenorphine subdermal implant and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits CYP3A4, which metabolizes buprenorphine, so exposure may rise. The implant cannot be dose-adjusted, so overmedication with sedation or respiratory depression is harder to manage.
What this interaction means in plain words
Buprenorphine subdermal implant and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by isoniazid reduces buprenorphine metabolism.
What to do
Monitor for sedation, respiratory depression and signs of overmedication; if they occur, consider implant removal and use an adjustable buprenorphine form.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Buprenorphine subdermal implant and Isoniazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Frequently asked questions
Can I take Buprenorphine subdermal implant with Isoniazid?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid inhibits CYP3A4, which metabolizes buprenorphine, so exposure may rise. The implant cannot be dose-adjusted, so overmedication with sedation or respiratory depression is harder to manage.
How serious is the interaction between Buprenorphine subdermal implant and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and signs of overmedication; if they occur, consider implant removal and use an adjustable buprenorphine form.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
