Drug interactions
Buprenorphine subdermal implant + Olanzapine
Severity: Moderate
Buprenorphine subdermal implant and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can modestly prolong the QT interval, so combined use may add to arrhythmia risk in predisposed patients. Olanzapine's QT effect is generally small. Additive sedation is also possible.
What this interaction means in plain words
Buprenorphine subdermal implant and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization, plus additive CNS depression.
What to do
Check a baseline ECG if the patient has other QT risk factors, and correct electrolyte abnormalities. Monitor for palpitations, syncope and excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Frequently asked questions
Can I take Buprenorphine subdermal implant with Olanzapine?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can modestly prolong the QT interval, so combined use may add to arrhythmia risk in predisposed patients. Olanzapine's QT effect is generally small. Additive sedation is also possible.
How serious is the interaction between Buprenorphine subdermal implant and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG if the patient has other QT risk factors, and correct electrolyte abnormalities. Monitor for palpitations, syncope and excessive sedation.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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