Drug interactions
Busulfan + Dacarbazine
Severity: Moderate
Busulfan and Dacarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are myelosuppressive, so combining them can increase the depth and duration of cytopenias. This raises the risk of infection and bleeding.
What this interaction means in plain words
Busulfan and Dacarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Busulfan belongs to Oncology; Dacarbazine belongs to Oncology.
Why it happens
Additive bone marrow suppression from two cytotoxic alkylating agents.
What to do
Monitor complete blood counts frequently. Adjust doses or delay cycles based on neutrophil and platelet recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dacarbazine
Other interactions of Busulfan
- Busulfan + Carboplatin Major
- Busulfan + Chlorambucil Major
- Busulfan + Cyclophosphamide Major
- Busulfan + Fingolimod Major
- Busulfan + Hydroxycarbamide Major
- Busulfan + Ifosfamide Major
Frequently asked questions
Can I take Busulfan with Dacarbazine?
MediHelp rates the interaction as moderate. Busulfan and Dacarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are myelosuppressive, so combining them can increase the depth and duration of cytopenias. This raises the risk of infection and bleeding.
How serious is the interaction between Busulfan and Dacarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently. Adjust doses or delay cycles based on neutrophil and platelet recovery.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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