Drug interactions
Butabarbital + Captopril
Severity: Minor
Butabarbital and Captopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can lower blood pressure and cause orthostatic hypotension, which may add to the effect of captopril. Sedation may also make dizziness and falls more likely.
What this interaction means in plain words
Butabarbital and Captopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypotensive effects from CNS depression and vasodilation combined with ACE inhibition.
What to do
Monitor blood pressure and counsel patients about orthostatic dizziness. Adjust the antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Butabarbital with Captopril?
MediHelp rates the interaction as minor. Butabarbital and Captopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates can lower blood pressure and cause orthostatic hypotension, which may add to the effect of captopril. Sedation may also make dizziness and falls more likely.
How serious is the interaction between Butabarbital and Captopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel patients about orthostatic dizziness. Adjust the antihypertensive dose if hypotension develops.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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