Drug interactions
Butabarbital + Carvedilol
Severity: Moderate
Butabarbital and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital may lower carvedilol concentrations and reduce its effect on blood pressure and heart rate. The effect develops gradually with continued barbiturate use.
What this interaction means in plain words
Butabarbital and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of hepatic enzymes such as CYP2C9 and CYP2D6 increases carvedilol clearance.
What to do
Monitor blood pressure and heart rate and increase carvedilol dose if response is inadequate. Reassess when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Butabarbital with Carvedilol?
MediHelp rates the interaction as moderate. Butabarbital and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital may lower carvedilol concentrations and reduce its effect on blood pressure and heart rate. The effect develops gradually with continued barbiturate use.
How serious is the interaction between Butabarbital and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and increase carvedilol dose if response is inadequate. Reassess when the barbiturate is stopped.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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