Drug interactions
Butabarbital + Darifenacin
Severity: Moderate
Butabarbital and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is an inducer of hepatic enzymes including CYP3A4, which may lower darifenacin concentrations and reduce control of overactive bladder symptoms. Both drugs may also contribute to CNS effects such as sedation.
What this interaction means in plain words
Butabarbital and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP3A4 increases darifenacin metabolism.
What to do
Monitor bladder symptom control and increase the darifenacin dose if needed within labeled limits, or consider an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Butabarbital and Darifenacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Darifenacin
Frequently asked questions
Can I take Butabarbital with Darifenacin?
MediHelp rates the interaction as moderate. Butabarbital and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital is an inducer of hepatic enzymes including CYP3A4, which may lower darifenacin concentrations and reduce control of overactive bladder symptoms. Both drugs may also contribute to CNS effects such as sedation.
How serious is the interaction between Butabarbital and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bladder symptom control and increase the darifenacin dose if needed within labeled limits, or consider an alternative.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
