Drug interactions
Butabarbital + Dextroamphetamine
Severity: Minor
Butabarbital and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is a sedative and dextroamphetamine a stimulant, so they have opposing effects on alertness. Barbiturates are also CYP inducers but amphetamine is mostly renally cleared, so the effect on levels is minor. The stimulant may mask sedation.
What this interaction means in plain words
Butabarbital and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS pharmacodynamic effects.
What to do
Monitor for loss of efficacy of either drug and for excessive sedation. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Butabarbital with Dextroamphetamine?
MediHelp rates the interaction as minor. Butabarbital and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butabarbital is a sedative and dextroamphetamine a stimulant, so they have opposing effects on alertness. Barbiturates are also CYP inducers but amphetamine is mostly renally cleared, so the effect on levels is minor. The stimulant may mask sedation.
How serious is the interaction between Butabarbital and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy of either drug and for excessive sedation. No routine dose change is needed.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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