Drug interactions
Butabarbital + Diltiazem
Severity: Moderate
Butabarbital and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital, a barbiturate, can induce hepatic and intestinal enzymes and lower diltiazem exposure. This may reduce control of blood pressure, angina or heart rate.
What this interaction means in plain words
Butabarbital and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases the first-pass and systemic metabolism of diltiazem.
What to do
Monitor heart rate, blood pressure and anginal symptoms, and increase the diltiazem dose if response is lost. Reassess the dose if the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Butabarbital with Diltiazem?
MediHelp rates the interaction as moderate. Butabarbital and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital, a barbiturate, can induce hepatic and intestinal enzymes and lower diltiazem exposure. This may reduce control of blood pressure, angina or heart rate.
How serious is the interaction between Butabarbital and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and anginal symptoms, and increase the diltiazem dose if response is lost. Reassess the dose if the barbiturate is stopped.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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