Drug interactions
Butabarbital + Donepezil
Severity: Minor
Butabarbital and Donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital induces hepatic enzymes including CYP3A4 and may reduce donepezil concentrations. This could lessen its cognitive benefit, and the two may also have opposing CNS effects.
What this interaction means in plain words
Butabarbital and Donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 increasing donepezil clearance.
What to do
Monitor for loss of cognitive response and titrate donepezil as needed. Consider an alternative sedative if efficacy declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Butabarbital with Donepezil?
MediHelp rates the interaction as minor. Butabarbital and Donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butabarbital induces hepatic enzymes including CYP3A4 and may reduce donepezil concentrations. This could lessen its cognitive benefit, and the two may also have opposing CNS effects.
How serious is the interaction between Butabarbital and Donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of cognitive response and titrate donepezil as needed. Consider an alternative sedative if efficacy declines.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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