Drug interactions
Butabarbital + Etoposide
Severity: Moderate
Butabarbital and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are enzyme inducers and can increase the metabolism of etoposide, which may lower its concentrations. Reduced exposure could decrease antitumor efficacy.
What this interaction means in plain words
Butabarbital and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by butabarbital increases etoposide clearance.
What to do
Use a non-inducing sedative or anticonvulsant where possible. If the combination is unavoidable, monitor treatment response closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Butabarbital with Etoposide?
MediHelp rates the interaction as moderate. Butabarbital and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are enzyme inducers and can increase the metabolism of etoposide, which may lower its concentrations. Reduced exposure could decrease antitumor efficacy.
How serious is the interaction between Butabarbital and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing sedative or anticonvulsant where possible. If the combination is unavoidable, monitor treatment response closely.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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