Drug interactions
Butabarbital + Exemestane
Severity: Moderate
Butabarbital and Exemestane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4, which can lower exemestane concentrations and weaken its estrogen suppression. This may compromise breast cancer treatment.
What this interaction means in plain words
Butabarbital and Exemestane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases exemestane clearance.
What to do
Avoid the combination where feasible. If it is needed, exemestane labeling recommends 50 mg daily after a meal with a strong CYP3A4 inducer.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Exemestane
Frequently asked questions
Can I take Butabarbital with Exemestane?
MediHelp rates the interaction as moderate. Butabarbital and Exemestane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4, which can lower exemestane concentrations and weaken its estrogen suppression. This may compromise breast cancer treatment.
How serious is the interaction between Butabarbital and Exemestane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where feasible. If it is needed, exemestane labeling recommends 50 mg daily after a meal with a strong CYP3A4 inducer.
What other medicines interact with Exemestane?
MediHelp also lists interactions of Exemestane with, for example, Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol. The full list is on the Exemestane page.
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