Drug interactions
Butabarbital + Griseofulvin
Severity: Moderate
Butabarbital and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates have been reported to reduce griseofulvin activity, probably by lowering its absorption and possibly by enzyme induction. Treatment of fungal infection may fail as a result.
What this interaction means in plain words
Butabarbital and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced oral absorption and possible hepatic enzyme induction by the barbiturate lower griseofulvin levels.
What to do
Monitor clinical response to antifungal therapy and consider a higher griseofulvin dose or an alternative antifungal if the response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Butabarbital with Griseofulvin?
MediHelp rates the interaction as moderate. Butabarbital and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates have been reported to reduce griseofulvin activity, probably by lowering its absorption and possibly by enzyme induction. Treatment of fungal infection may fail as a result.
How serious is the interaction between Butabarbital and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to antifungal therapy and consider a higher griseofulvin dose or an alternative antifungal if the response is poor.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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