Drug interactions
Butabarbital + Lansoprazole
Severity: Minor
Butabarbital and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are enzyme inducers and may lower lansoprazole concentrations, potentially reducing acid suppression. The clinical effect is probably small.
What this interaction means in plain words
Butabarbital and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of CYP2C19 and CYP3A4 increases lansoprazole metabolism.
What to do
Monitor symptom control and increase the lansoprazole dose if acid suppression appears inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Butabarbital with Lansoprazole?
MediHelp rates the interaction as minor. Butabarbital and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates are enzyme inducers and may lower lansoprazole concentrations, potentially reducing acid suppression. The clinical effect is probably small.
How serious is the interaction between Butabarbital and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and increase the lansoprazole dose if acid suppression appears inadequate.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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