Drug interactions
Butabarbital + Triprolidine
Severity: Moderate
Butabarbital and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are potent CNS depressants, and adding a sedating antihistamine can deepen sedation and impair alertness and coordination. High doses or vulnerable patients may experience marked CNS and respiratory depression.
What this interaction means in plain words
Butabarbital and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation by the barbiturate and H1 receptor blockade.
What to do
Counsel on drowsiness and avoid driving or hazardous tasks. Use a non-sedating antihistamine and monitor sedation, particularly in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Frequently asked questions
Can I take Butabarbital with Triprolidine?
MediHelp rates the interaction as moderate. Butabarbital and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are potent CNS depressants, and adding a sedating antihistamine can deepen sedation and impair alertness and coordination. High doses or vulnerable patients may experience marked CNS and respiratory depression.
How serious is the interaction between Butabarbital and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoid driving or hazardous tasks. Use a non-sedating antihistamine and monitor sedation, particularly in older adults.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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