Drug interactions
Butalbital + Captopril
Severity: Minor
Butalbital and Captopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that can contribute to hypotension and sedation. Combined with captopril, blood pressure lowering may be enhanced, though clinically significant effects are uncommon.
What this interaction means in plain words
Butalbital and Captopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypotensive effects from barbiturate CNS depression and ACE inhibition.
What to do
Monitor blood pressure when butalbital is started and advise patients to rise slowly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Butalbital with Captopril?
MediHelp rates the interaction as minor. Butalbital and Captopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate that can contribute to hypotension and sedation. Combined with captopril, blood pressure lowering may be enhanced, though clinically significant effects are uncommon.
How serious is the interaction between Butalbital and Captopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when butalbital is started and advise patients to rise slowly.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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