Drug interactions
Butalbital + Carvedilol
Severity: Minor
Butalbital and Carvedilol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital, a barbiturate, may reduce carvedilol exposure with repeated use, potentially weakening blood pressure or heart failure benefit. Occasional use is unlikely to matter.
What this interaction means in plain words
Butalbital and Carvedilol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated enzyme induction increases hepatic metabolism of carvedilol.
What to do
Monitor blood pressure and heart rate if butalbital is used frequently, and adjust carvedilol dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Butalbital with Carvedilol?
MediHelp rates the interaction as minor. Butalbital and Carvedilol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital, a barbiturate, may reduce carvedilol exposure with repeated use, potentially weakening blood pressure or heart failure benefit. Occasional use is unlikely to matter.
How serious is the interaction between Butalbital and Carvedilol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate if butalbital is used frequently, and adjust carvedilol dose accordingly.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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