Drug interactions
Butalbital + Clemastine
Severity: Moderate
Butalbital and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate, and a sedating antihistamine adds to drowsiness, dizziness and impaired concentration. Higher doses raise the risk of respiratory depression.
What this interaction means in plain words
Butalbital and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from barbiturate GABA-A potentiation and central H1 receptor blockade.
What to do
Use the lowest effective doses and monitor for oversedation. Advise avoiding alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Frequently asked questions
Can I take Butalbital with Clemastine?
MediHelp rates the interaction as moderate. Butalbital and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate, and a sedating antihistamine adds to drowsiness, dizziness and impaired concentration. Higher doses raise the risk of respiratory depression.
How serious is the interaction between Butalbital and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation. Advise avoiding alcohol and driving until the response is known.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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