Drug interactions
Butalbital + Darifenacin
Severity: Moderate
Butalbital and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital, a barbiturate, can induce hepatic and intestinal CYP3A4 and lower darifenacin exposure. This may reduce control of overactive bladder symptoms.
What this interaction means in plain words
Butalbital and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases the metabolism of darifenacin.
What to do
Monitor for loss of bladder symptom control during and after butalbital use. Increase the darifenacin dose within labeled limits or choose an alternative if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Frequently asked questions
Can I take Butalbital with Darifenacin?
MediHelp rates the interaction as moderate. Butalbital and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital, a barbiturate, can induce hepatic and intestinal CYP3A4 and lower darifenacin exposure. This may reduce control of overactive bladder symptoms.
How serious is the interaction between Butalbital and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of bladder symptom control during and after butalbital use. Increase the darifenacin dose within labeled limits or choose an alternative if efficacy is lost.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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