Drug interactions
Butalbital + Diltiazem
Severity: Moderate
Butalbital and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with enzyme-inducing potential that may reduce diltiazem concentrations. Reduced antihypertensive or antianginal effect is possible, especially with regular use.
What this interaction means in plain words
Butalbital and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-related induction of CYP3A4 accelerates diltiazem metabolism.
What to do
Monitor blood pressure and heart rate or angina control when butalbital is used regularly, and titrate diltiazem upward if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Butalbital with Diltiazem?
MediHelp rates the interaction as moderate. Butalbital and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate with enzyme-inducing potential that may reduce diltiazem concentrations. Reduced antihypertensive or antianginal effect is possible, especially with regular use.
How serious is the interaction between Butalbital and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate or angina control when butalbital is used regularly, and titrate diltiazem upward if needed.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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