Drug interactions
Butalbital + Lansoprazole
Severity: Minor
Butalbital and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital may induce hepatic enzymes and reduce lansoprazole exposure, potentially weakening acid suppression. Clinical relevance is likely limited with intermittent use.
What this interaction means in plain words
Butalbital and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Enzyme induction of CYP2C19 and CYP3A4 increases lansoprazole clearance.
What to do
Monitor symptom control, and increase lansoprazole dose if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Butalbital with Lansoprazole?
MediHelp rates the interaction as minor. Butalbital and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital may induce hepatic enzymes and reduce lansoprazole exposure, potentially weakening acid suppression. Clinical relevance is likely limited with intermittent use.
How serious is the interaction between Butalbital and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control, and increase lansoprazole dose if response is inadequate.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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