Drug interactions
Butalbital + Pimozide
Severity: Moderate
Butalbital and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that adds CNS depression to pimozide's sedative effect. It may also modestly induce metabolism of pimozide.
What this interaction means in plain words
Butalbital and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible weak enzyme induction by the barbiturate.
What to do
Limit butalbital use to the lowest effective dose and frequency, and monitor for sedation. Warn patients about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Butalbital with Pimozide?
MediHelp rates the interaction as moderate. Butalbital and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that adds CNS depression to pimozide's sedative effect. It may also modestly induce metabolism of pimozide.
How serious is the interaction between Butalbital and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit butalbital use to the lowest effective dose and frequency, and monitor for sedation. Warn patients about driving and alcohol.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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