Drug interactions
Butalbital + Praziquantel
Severity: Major
Butalbital and Praziquantel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate and enzyme inducer that can lower praziquantel levels. This may cause treatment failure.
What this interaction means in plain words
Butalbital and Praziquantel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 induction by butalbital increases praziquantel metabolism.
What to do
Avoid butalbital during praziquantel therapy, particularly for short courses, and use an alternative analgesic. If unavoidable, confirm parasitological response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Carbamazepine + Praziquantel Major
Frequently asked questions
Can I take Butalbital with Praziquantel?
MediHelp rates the interaction as major. Butalbital and Praziquantel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Butalbital is a barbiturate and enzyme inducer that can lower praziquantel levels. This may cause treatment failure.
How serious is the interaction between Butalbital and Praziquantel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid butalbital during praziquantel therapy, particularly for short courses, and use an alternative analgesic. If unavoidable, confirm parasitological response.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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