Drug interactions
Butalbital + Rabeprazole
Severity: Minor
Butalbital and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP2C19 and CYP3A4 and could lower rabeprazole exposure. The effect is expected to be small because of rabeprazole's non-enzymatic clearance.
What this interaction means in plain words
Butalbital and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated enzyme induction may increase rabeprazole clearance.
What to do
Monitor for reduced acid control and increase the rabeprazole dose if symptoms persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Butalbital with Rabeprazole?
MediHelp rates the interaction as minor. Butalbital and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate that may induce CYP2C19 and CYP3A4 and could lower rabeprazole exposure. The effect is expected to be small because of rabeprazole's non-enzymatic clearance.
How serious is the interaction between Butalbital and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced acid control and increase the rabeprazole dose if symptoms persist.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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