Drug interactions
Butalbital + Topiramate
Severity: Moderate
Butalbital and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate and adds to the sedative and cognitive effects of topiramate. Patients may experience excessive drowsiness, dizziness, confusion and impaired psychomotor performance.
What this interaction means in plain words
Butalbital and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects from GABAergic barbiturate activity and topiramate.
What to do
Use the lowest effective butalbital dose and limit frequency of use. Advise patients to avoid driving or hazardous tasks until the response is known and to avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Frequently asked questions
Can I take Butalbital with Topiramate?
MediHelp rates the interaction as moderate. Butalbital and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate and adds to the sedative and cognitive effects of topiramate. Patients may experience excessive drowsiness, dizziness, confusion and impaired psychomotor performance.
How serious is the interaction between Butalbital and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective butalbital dose and limit frequency of use. Advise patients to avoid driving or hazardous tasks until the response is known and to avoid alcohol.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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