Drug interactions
Butorphanol + Clemastine
Severity: Moderate
Butorphanol and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating antihistamine that can intensify opioid-related drowsiness and impair alertness. Elderly patients are especially vulnerable.
What this interaction means in plain words
Butorphanol and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Clemastine belongs to Respiratory.
Why it happens
Additive CNS depression from central H1-receptor blockade and opioid activity.
What to do
Advise avoiding driving and alcohol and monitor sedation; use a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Clemastine
Frequently asked questions
Can I take Butorphanol with Clemastine?
MediHelp rates the interaction as moderate. Butorphanol and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating antihistamine that can intensify opioid-related drowsiness and impair alertness. Elderly patients are especially vulnerable.
How serious is the interaction between Butorphanol and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding driving and alcohol and monitor sedation; use a non-sedating antihistamine where possible.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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