Drug interactions
Butorphanol + Dexfenfluramine
Severity: Minor
Butorphanol and Dexfenfluramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine has been withdrawn from the market, and no reliable clinical interaction with butorphanol is documented. Any effect on sedation is theoretical.
What this interaction means in plain words
Butorphanol and Dexfenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; possible serotonergic effects are theoretical.
What to do
No specific action is needed beyond routine monitoring of sedation. The drug is not available in most markets.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Dexfenfluramine?
MediHelp rates the interaction as minor. Butorphanol and Dexfenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexfenfluramine has been withdrawn from the market, and no reliable clinical interaction with butorphanol is documented. Any effect on sedation is theoretical.
How serious is the interaction between Butorphanol and Dexfenfluramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of sedation. The drug is not available in most markets.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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