Drug interactions
Butorphanol + Diethylpropion
Severity: Minor
Butorphanol and Diethylpropion: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butorphanol is a sedating opioid agonist-antagonist and diethylpropion is a sympathomimetic anorectic stimulant. Their CNS effects partly oppose each other, so stimulation may hide opioid sedation, and the net effect is unpredictable.
What this interaction means in plain words
Butorphanol and Diethylpropion have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no established pharmacokinetic interaction.
What to do
Monitor sedation and respiratory rate after butorphanol doses rather than relying on alertness alone. Also watch blood pressure and heart rate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Diethylpropion?
MediHelp rates the interaction as minor. Butorphanol and Diethylpropion have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butorphanol is a sedating opioid agonist-antagonist and diethylpropion is a sympathomimetic anorectic stimulant. Their CNS effects partly oppose each other, so stimulation may hide opioid sedation, and the net effect is unpredictable.
How serious is the interaction between Butorphanol and Diethylpropion?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate after butorphanol doses rather than relying on alertness alone. Also watch blood pressure and heart rate.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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