Drug interactions
Butorphanol + Epinephrine
Severity: Minor
Butorphanol and Epinephrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine has no sedative action, so no meaningful additive sedation occurs. Both drugs can influence cardiovascular parameters, but there is no established clinically important interaction.
What this interaction means in plain words
Butorphanol and Epinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Butorphanol belongs to Musculoskeletal; Epinephrine belongs to Endocrine.
Why it happens
No established mechanism; only theoretical hemodynamic overlap.
What to do
No adjustment is required. Monitor blood pressure and heart rate when both are used in acute settings.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Butorphanol with Epinephrine?
MediHelp rates the interaction as minor. Butorphanol and Epinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epinephrine has no sedative action, so no meaningful additive sedation occurs. Both drugs can influence cardiovascular parameters, but there is no established clinically important interaction.
How serious is the interaction between Butorphanol and Epinephrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required. Monitor blood pressure and heart rate when both are used in acute settings.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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