Drug interactions
Butorphanol + Loxapine inhaled
Severity: Moderate
Butorphanol and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine is a sedating antipsychotic that can cause bronchospasm and somnolence, and butorphanol adds opioid CNS depression. Together they may cause excessive sedation and respiratory compromise.
What this interaction means in plain words
Butorphanol and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid agonism and antipsychotic receptor blockade.
What to do
Monitor sedation and respiratory status after loxapine inhalation, and reduce the butorphanol dose where appropriate. Use only in a supervised setting with the required bronchospasm precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Loxapine inhaled?
MediHelp rates the interaction as moderate. Butorphanol and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine is a sedating antipsychotic that can cause bronchospasm and somnolence, and butorphanol adds opioid CNS depression. Together they may cause excessive sedation and respiratory compromise.
How serious is the interaction between Butorphanol and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status after loxapine inhalation, and reduce the butorphanol dose where appropriate. Use only in a supervised setting with the required bronchospasm precautions.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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