Drug interactions
Butorphanol + Marijuana
Severity: Moderate
Butorphanol and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis produces sedation and psychomotor impairment, and butorphanol adds opioid CNS depression. Together they may impair alertness and judgment and add to dizziness and respiratory depression.
What this interaction means in plain words
Butorphanol and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via cannabinoid and opioid receptor effects.
What to do
Counsel patients to avoid cannabis while taking butorphanol, and avoid driving. Monitor for excessive sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Marijuana?
MediHelp rates the interaction as moderate. Butorphanol and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis produces sedation and psychomotor impairment, and butorphanol adds opioid CNS depression. Together they may impair alertness and judgment and add to dizziness and respiratory depression.
How serious is the interaction between Butorphanol and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid cannabis while taking butorphanol, and avoid driving. Monitor for excessive sedation and respiratory depression.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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