Drug interactions
Butorphanol + Methylenedioxymethamphetamine
Severity: Moderate
Butorphanol and Methylenedioxymethamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a stimulant that can mask opioid sedation, while butorphanol may depress breathing and consciousness. MDMA also raises heart rate, blood pressure and temperature and has serotonergic effects, so the combination is unpredictable and risky.
What this interaction means in plain words
Butorphanol and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS arousal effects with MDMA-induced serotonin release and sympathomimetic stimulation; no established pharmacokinetic interaction.
What to do
Advise against use of MDMA with butorphanol. Monitor vital signs, temperature, sedation and respiration, and watch for serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Methylenedioxymethamphetamine?
MediHelp rates the interaction as moderate. Butorphanol and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is a stimulant that can mask opioid sedation, while butorphanol may depress breathing and consciousness. MDMA also raises heart rate, blood pressure and temperature and has serotonergic effects, so the combination is unpredictable and risky.
How serious is the interaction between Butorphanol and Methylenedioxymethamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against use of MDMA with butorphanol. Monitor vital signs, temperature, sedation and respiration, and watch for serotonin toxicity.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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