Drug interactions
Butorphanol + Metoclopramide intranasal
Severity: Moderate
Butorphanol and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastric emptying and gut motility, which opposes the prokinetic action of metoclopramide. Both drugs can also cause CNS effects such as drowsiness, so sedation may be additive.
What this interaction means in plain words
Butorphanol and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opioid-mediated reduction in gastrointestinal motility antagonizes metoclopramide's prokinetic effect, with additive CNS depression.
What to do
Monitor for reduced metoclopramide efficacy and for sedation. Consider an alternative analgesic if gastroparesis symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Butorphanol and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastric emptying and gut motility, which opposes the prokinetic action of metoclopramide. Both drugs can also cause CNS effects such as drowsiness, so sedation may be additive.
How serious is the interaction between Butorphanol and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced metoclopramide efficacy and for sedation. Consider an alternative analgesic if gastroparesis symptoms worsen.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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