Drug interactions
Butorphanol + Moxonidine
Severity: Moderate
Butorphanol and Moxonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine is a centrally acting antihypertensive that can cause drowsiness and dizziness. Combined with butorphanol, sedation and hypotension may be more pronounced.
What this interaction means in plain words
Butorphanol and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects from central imidazoline receptor agonism and opioid receptor activity.
What to do
Monitor sedation level and blood pressure, especially when starting or increasing doses. Counsel patients on avoiding driving and rising slowly from sitting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Moxonidine?
MediHelp rates the interaction as moderate. Butorphanol and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine is a centrally acting antihypertensive that can cause drowsiness and dizziness. Combined with butorphanol, sedation and hypotension may be more pronounced.
How serious is the interaction between Butorphanol and Moxonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and blood pressure, especially when starting or increasing doses. Counsel patients on avoiding driving and rising slowly from sitting.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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