Drug interactions
Butorphanol + Olanzapine
Severity: Moderate
Butorphanol and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating, and combined use can cause excessive drowsiness, dizziness, orthostatic hypotension and respiratory depression. Parenteral olanzapine with opioids warrants particular care.
What this interaction means in plain words
Butorphanol and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid receptor agonism and antihistaminic, antimuscarinic and antiadrenergic effects of olanzapine.
What to do
Monitor sedation, blood pressure and respiration, and begin with reduced doses. Separate parenteral doses and avoid concurrent IM olanzapine with high-dose opioids if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Butorphanol with Olanzapine?
MediHelp rates the interaction as moderate. Butorphanol and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating, and combined use can cause excessive drowsiness, dizziness, orthostatic hypotension and respiratory depression. Parenteral olanzapine with opioids warrants particular care.
How serious is the interaction between Butorphanol and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and respiration, and begin with reduced doses. Separate parenteral doses and avoid concurrent IM olanzapine with high-dose opioids if possible.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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