Drug interactions
Butorphanol + Olopatadine intranasal
Severity: Minor
Butorphanol and Olopatadine intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause drowsiness in some patients, and butorphanol is a sedating opioid. Together they may increase drowsiness and impair psychomotor performance, though systemic exposure to olopatadine is low.
What this interaction means in plain words
Butorphanol and Olopatadine intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression from the opioid and the sedating antihistamine.
What to do
Counsel patients to avoid driving or hazardous tasks until response is known. Reduce use of olopatadine if excessive drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Olopatadine intranasal?
MediHelp rates the interaction as minor. Butorphanol and Olopatadine intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intranasal olopatadine can cause drowsiness in some patients, and butorphanol is a sedating opioid. Together they may increase drowsiness and impair psychomotor performance, though systemic exposure to olopatadine is low.
How serious is the interaction between Butorphanol and Olopatadine intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving or hazardous tasks until response is known. Reduce use of olopatadine if excessive drowsiness occurs.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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